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Leicestershire Centre for Integrated Living

Teenage boy with rare brain cancer among first in UK to receive proton beam therapy

Date: 24/1/2019
Summary: PROTON beam therapy is a type of particle therapy that uses a beam of protons to irradiate diseased tissue. Now, a 15-year-old with a rare brain tumour is to undergo the procedure at the first NHS centre to offer this treatment.

Mason Kettley, from Angmering in West Sussex, will receive the highly targeted therapy which helps shrink cancerous tumours  and cuts the risk of side-effects. It will be carried out by the Christie NHS Foundation Trust in Manchester - home to the world's newest proton beam therapy centre. Mason is one of the first patients to undergo proton beam therapy in the UK and the first to go public. Until now, British patients needing the treatment had to travel to countries including the US.

He was diagnosed with an inoperable tumour in October after suffering headaches and failing to put on weight.

Doctors found that the tumour was growing in a critical part of his brain but could not operate due to the risk of causing blindness and damage to vital brain tissue.

Science-loving Mason, who wants to work as a doctor specialising in tumours when he is older, said he did not initially have many symptoms.

He said: "I had some headaches and stomach pains and usual things, and got check-ups at the doctors.

"My mum said, 'he's not gaining weight or growing', and eventually, when we moved last year, we saw doctors who told us to go to Worthing Hospital for an MRI scan.

"We had the scan and the result showed it was a tumour."

They decided that his tumour - known as a benign pilomyxoid astrocytoma - made him a suitable candidate for proton beam therapy.

Mason, who lives with mother Cally, stepfather Ryan and four siblings - Taylor, 20, Logan, 10, Scarlett, seven, and Elijah, four - said he feels apprehensive about the treatment.

He said: "I'm a bit nervous because the machine is intimidating because of its size.

"It's a bit nerve-wracking but this is a better choice than chemo because it's more effective. Because of my age, (doctors) thought radiation would be a better choice.

"Their goal is to stabilise the tumour. It may shrink, but they are aiming to stabilise it."

Mason will have treatment Monday to Friday for almost six weeks - 28 sessions in total.

He said: "The short-term effects are that you may vomit and get a headache now and then, but in the long term the side effects are rare."

Mason, who will sit GCSEs next year, will have six weeks off school.


Proton beam therapy is a highly targeted treatment which hits tumours much more precisely than conventional radiotherapy.

This makes it beneficial for patients with difficult-to-treat tumours in critical areas, such as in the brain or spinal cord, and for young people whose tissues are still developing.

Two new proton beam therapy centres have been built at The Christie and University College London Hospital (UCLH) with £250 million of Government money.

Consultant clinical oncologist Gillian Whitfield, who is leading Mason's care at The Christie, said: "With proton beam therapy, compared to conventional radiotherapy, there is less dose to surrounding normal tissues and less risk of permanent long-term effects of treatment.

"This is particularly important for children and teenagers with curable tumours, who will survive decades after treatment and are at much greater risk of serious long-term effects of treatment than adults.

"Mason's tumour is a low grade (slow growing) tumour with a high chance of cure.

"For Mason, in comparison to conventional radiotherapy, proton beam therapy should carry a lower risk of some important long-term side effects of treatment, particularly effects on short-term memory and learning ability and the risk over the next eight decades of the radiation causing other tumours."

Professor Stephen Powis, medical director for the NHS in England added: "This is a hugely exciting development for the NHS and we are delighted that we are able to provide this life-changing treatment for patients like Mason."

A girl who was blinded in one eye was able to see again after undergoing proton therapy treatment in the USA.

Source: Express

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